Antagonists

Ryan:
Once a friend and travelling companion, now an enemy, Ryan has been around since our intrepid heroes first stumbled into the multiverse. Ryan was once a US Army Ranger, then a medical technician. Since stepping into the multiverse he has graduated to being a vampire, then an antediluvian, and finally becoming the favoured son and servitor of a powerful being from the Fading Suns 'verse, known as the Dark Whisperer in the Void, or more affectionately, the Angry Space God. He has slaughtered millions (literally) in order to fuel his rise to power, and is responsible (aided by Sally) for the nuclear destruction of at least one world.

He is currently acting as the Baali antediluvian in at least one of the WoD 'verses, and is busy spreading his clan of blue eyed and infernal vampires across the multiverse.

Ryan is skilled in almost all the vampiric disciplines, but has a particular affinity for auspex, dominate, fortitude, vicissitude and the strange discipline created by the Tphenis bloodline. He also has near total mastery of his patron's weird blue flame, that can entirely obliterate another being within seconds. He is awesomely powerful, utterly malevolent, and very American.

Ryan's children are marked by their unearthly blue eyes, and by the method of their creation, which involved their hearts being removed. They are also all stupid.

They also don't like Fidelacchius. Which is nice.

The Angry Space God:
Ryan's patron, a qlippothic being from the Fading Suns 'verse, where for millennia it was trapped in the Sutekh jumpgate. It can move people through space and time, obliterate almost anything with its blue flame, and likes human sacrifice, although it will take whatever is going.

It may dislike the travellers, but has brought three of them back to life at least once, and hasn't ever actively tried to kill them, which seems to imply it sees a use for them yet.

The Zodiac:
A group of world hopping villains. Every encounter they have had with Sally and Ginnie has gone badly, but apparently they are reasonably well inclined towards MattMatt. They also have some associations with Aidan Aderyn, which may or may not influence their attitudes in the future. They have recently (as of Series 5) got in touch about a possible job for our intrepid heroes; the successful completion of which will negate any outstanding bad blood. ...Yeah, we can see the ways this can go well, too. They have a secret base on the moon, and a technological way of teleporting, which includes cross-dimension.

They comprise at least: Scorpio Leo (Jez' ex Ellie) - a cat-shifter who's insanely lucky because of a shard of the walls of Absalom she carries Taurus (Giant bull-man with cybernetic arm) Aries? Capricorn (the Piper; 'Don't mess with him') Gemini - can clone himself? May be related to the crazed Aryan supremacist PYFavs killed?

They are all part of the Millenium Foundation, along with Stone, Aderyn and a few others. Aries: Hard hitter, physicalist.

Taurus: Giant bull-man with cybernetic arm.

Gemini: Possesses two demons, one with magic, one with power over machines. Eat his face.

Cancer: Giant rocky pincer-clawed physicalist; honourable, straightforward, all the mind shields of a Mattmatt.

Leo: Jez' ex Ellie; cat-shifter, insanely lucky because of a shard of the walls of Absalom she carries.

Virgo: Psionic from the 80s, purple-jumpsuited telepath.

Libra:

Scorpio: Ninja who turns to smoke (negated by electricity? Immune to phys, not to energy?), psychically invisible, once tried to murder Sally.

Saggitarius: Short redhead, insanely accurate shot (over truly ridiculous distances). Shoots... bolts of ice? Maybe glass cannon.

Capricorn: The Great God Pan, the Piper. Quite a nice guy, really. Don't mess with him.

Aquarius:

Pisces: ...Some kind of mermaid?

House Aderyn:
A noble house, based out of the Fading Suns 'verse, founded by Aidan Aderyn, who was once a world hopper, gifted with the power of the phoenix force. He came to the Fading Suns 'verse posing as a noble from a Lost World, and traded an empty planet to Prince Hyram Decados in return for a title. Aderyn's Phoenix-shard puts him at around the 17th most powerful rung of people in the multiverse, according to Walker.

Aidan Aderyn's issues with the current group of travellers is mostly because three of them appear as apostle figures in a dubious and antimoniacal religion founded by their previous travelling companion, Ryan, and also because they have accidentally pushed his mistress out into a variety of hostile worlds whilst passing through.

The party's past association with Ryan really doesn't help either, as Ryan is responsible for the death of tens of thousands of people on the planet of Sutekh, and released a major infernal being from its prison on this world. Oh, and he introduced the Baali to the Fading Suns 'verse. All in all, quite a lot of reasons for House Aderyn to not be too keen.

Antonio Villanova:
A Vodacce of flexible morality from the 7th Sea 'verse. He's been yanked out of his own world and abandoned by the travellers once, and then yanked out of his new home world another time. Not to mention Elle revealing some of his deeper secrets once as well. In general, I think we can assume that his intentions are not kindly. On the bright side, as of the end of Series 4, our noble heroes dropped him off near Freiberg in Eisen, and he seems to be happy to let bygones be bygones. And to introduce modern firepower to the Seventh Sea 'verse. We can only hope that dramatic necessity reduces him to merely moustache-twirling instead of villainously efficient...